红景天胶囊对兔急性心肌缺血再灌注损伤的保护作用

目的 研究红景天胶囊对兔急性心肌缺血再灌注损伤的的影响及其保护机制.方法 实验选取10只健康日本大耳白兔为假手术组,另取20只随机分为模型组及红景天组,2组均采用手术结扎左侧冠状动脉前降支30 min后再灌注60min,反复3次以造成急性心肌缺血再灌注损伤动物模型.术后3组动物均灌胃给药,测定治疗前及治疗1、2周总超氧化物歧化酶(T-SOD)、一氧化氮(NO)、血管内皮素-1(ET-1)、血清丙二醛(MDA)、血清肌酸激酶(CK)、白细胞介素-6(IL-6)水平,记算治疗2周后兔心肌缺血梗死率(％)等指标,并分析红景天胶囊对兔急性心肌缺血再灌注损伤的影响.结果 红景天胶囊明显提高红景天组兔NO含量及T-SOD活性,降低ET-1及血清MDA、CK、IL-6水平,减少急性心肌缺血梗死率,与模型组比较,差异均有统计学意义(P＜0.05).结论 红景天胶囊可提高兔急性心肌缺血再灌注后T-SOD及NO活性,促进氧自由基清除酶清除氧自由基、降低心肌缺血时脂质过氧化,进而改善再灌注损伤后受损血管内皮并维持其正常功能,增加心肌组织耐缺氧能力,对急性心肌缺血再灌注具有保护作用.     

帕罗西汀联合丹栀逍遥丸治疗合并睡眠障碍的女性围绝经期抑郁症患者的疗效

目的：观察帕罗西汀联合丹栀逍遥丸对合并睡眠障碍的女性围绝经期抑郁症患者的治疗效果。方法行开放对照研究,单日就诊符合标准的患者为观察组（29例）,应用帕罗西汀联合丹栀逍遥丸治疗,双日为对照组（31例）,单用帕罗西汀治疗。4周后,通过检测治疗前后血浆雌二醇（E2）、促卵泡生成素（FSH）和促黄体生成素（LH）水平,采用改良的 Kupperman 评分量表、匹兹堡睡眠质量指数（PSQI）和汉密尔顿抑郁量表（HAMD）的评分变化评价临床疗效。结果对照组1例中途前往外地退出观察。治疗前两组性激素水平、躯体症状程度、PSQI 和 HAMD 的评分差异无统计学意义。治疗后两组患者血浆 E2水平均较治疗前增加,差异均有统计学意义（P ＜0．05）。观察组躯体症状明显减轻（Z ＝3．95,P ＜0．05）,而对照组变化不明显。治疗后两组 PSQI 和 HAMD 评分均有显著下降（P ＜0．01）,且观察组较对照组下降更显著,疗程末观察组的疗效优于对照组（P ＜0．05）。结论帕罗西汀能有效缓解女性围绝经期的抑郁症状及改善睡眠质量,联合丹栀逍遥丸治疗,疗效更佳。     

Repeat capsule endoscopy in suspected gastrointestinal bleeding

Objectives: This study aims to review the utility of repeat capsule endoscopy (CE) with on-going concern of small bowel (SB) bleeding following initial SB investigation with CE.

Materials and methods: A specifically designed database of CE examinations performed over 13 years, with hospital records, was retrospectively interrogated for patients undergoing multiple CEs to investigate iron deficiency anaemia (IDA) or suspected SB bleeding.

Results: 1335/2276 (58.7%) of CEs were performed to investigate IDA or SB bleeding; 92 were repeat CEs carried out for ongoing clinical concern. The median time interval between initial and repeat CE procedures was 466.5 (range 1–3066) days. Twenty-four patients had initially normal CE; on repeat examination, abnormalities were detected in 11/24 (45.8%). 3/21 (14.2%) of patients with angioectasia on first CE had alternative causes for IDA or GI bleeding detected on repeat CE. Six patients with active bleeding, without an identifiable source on initial CE, undergoing repeat CE had a cause isolated in 5/6 (83.3%). Changing CE device did not affect diagnostic yield (DY) compared to repeat CE using the same device (27.5% to 26.8%).

Conclusions: It is known that CE can miss clinically relevant and serious lesions. Our results suggest that patients with an initially negative or inconclusive CE frequently have a cause of SB bleeding detected on repeat CE. The DY of repeat CE is highest in those with bleeding on their initial CE (83.3%) and lower in those with initially normal examinations (45.8%) or when an alternative cause, such as angioectasia is seen (14.2%).     

胃溃疡应用健胃止溃胶囊的疗效探析

目的：对健胃止溃胶囊在胃溃疡治疗中的效果进行探究与分析。方法：对我院2013年7月～2014年7月收治的胃溃疡患者70例进行研究，将之随机分为常规组与改进组并行各自治疗方法，对两组的疗效进行对比分析。结果：两组总有效率及不良反应发生的情况并没有太大差别（P〉0．05），但改进组痊愈率要更加高，且有统计学意义（χ2=5．21，P〉0．05）。结论：健胃止渍胶囊对胃溃疡治疗效果的改善有促进作用，且使用后不良反应发生率有所下降，可在临床上进行推广。     

Tablet and Capsule Hydrophilic Matrices Based on Heterodisperse Polysaccharides Having Porosity-Independent In Vitro Release Profiles

The purpose of the study was to investigate the release-controlling action of a swellable hydrophilic material based on heterodisperse polysaccharides (HP) in relation to the initial pore structure of the formulations. HP-based granules were produced under carefully controlled conditions and compacted into matrix tablets having equivalent tablet thickness. Quantification of pore structure using mercury porosimetry showed that the tablets had substantially different pore volumes and pore size distributions. Dissolution studies demonstrated that release of a water-soluble model compound, benzamide, from swollen matrices was affected neither by total porosity nor median pore diameter of the initial dry matrix. To extend the concept of porosity-independent release further, HP-based formulations containing either diclofenac sodium or propranolol HCl were contained within hard gelatin capsules in the form of uncompacted granules. This produced a dosage form with a high intraparticulate porosity in the dry state. Equivalent weights of the same formulations were also compacted into tablets. The in vitro release profiles from matrix tablets compacted from any of the formulations did not differ significantly from release profiles obtained when the same materials were contained uncompacted in hard gelatin capsules.     

HPLC-ELSD法测定安多霖胶囊中黄芪甲苷

目的 建立高效液相色谱–蒸发光散射检测器（HPLC-ELSD）法测定安多霖胶囊中黄芪甲苷的方法。方法 采用Ultimate色谱柱（250 mm×4.6 mm，5 μm），流动相为乙腈–超纯水（32∶68），体积流量为1 mL/min，漂移管温度40 ℃，蒸发光散射检测器雾化气体为氮气，体积流量为2.7 L/min，载气压力350 kPa，进样量20 μL。结果 黄芪甲苷在1.59～10.60 μg呈良好的线性关系，r=0.999 5，平均回收率为99.11%，RSD为2.58%（n=6）。结论 本方法简便准确，重现性好，可用于安多霖胶囊的质量控制。     

囊袋收缩综合征的手术治疗

目的探讨白内障超声乳化术后囊袋收缩综合征的手术治疗效果。方法对12例（12只眼）白内障超声乳化术后并发囊袋收缩综合征进行囊袋松解术，观察术后视力及并发症情况。结果12只眼术后视力均有提高，10只眼视力〉10．4，2只眼视力0．1～0．3，无明显并发症发生。结论囊袋松解术是治疗重度囊袋收缩综合征的有效方法。     

Suicidal poisonings with methadone in France: Results of a two year national survey by the Toxicovigilance Network

Context. Methadone is used in France since March 1995, only for opioid maintenance treatment, in a syrup form. For the launching of a capsule form in April 2008, French health authorities requested a prospective survey of all cases involving exposure to methadone in either of the two available pharmaceutical forms. Objective. The aim was to document, in different circumstances and compare the safety of the new capsule form to the syrup. This report presents the findings of one arm of the study, devoted to methadone-related suicide attempts. Materials and method. From April 15, 2008 to April 15, 2010, all self-injurious methadone poisonings notified to or managed by the French Toxicovigilance Centers network were included. Analysis mainly focused on patients’ age and gender, estimated quantity ingested, eventual concomitantly taken substances, distribution of symptoms, and site of treatment. Results. 135 methadone-related suicide attempts were recorded. Analysis showed identical epidemiologic and clinical patient characteristics for the two pharmaceutical forms. Ten deaths occurred. The only discrepancy was a higher incidence of suicide attempts in the capsule group. However, as the number of capsule-treated patients increased during the second year, this difference remained significant but tended to decrease. Discussion. Combining these results with Pharmacovigilance and Addictovigilance arms, health authorities estimated that the benefit/risk balance of this new pharmaceutical form remains positive. They revised their position on requirements for prescribing and dispensing of the capsule form, and made them slightly easier. Following this, this “suicide” arm of Toxicovigilance survey was suspended, whereas the second one, concerning accidental pediatric methadone-related poisonings, has been extended until April 2014. Conclusion. In France, suicide attempts were more likely to occur with the capsule formulation. The clinical severity of intoxication was similar between the capsule and liquid forms.     

基于网络药理学及实验验证探究芪苈强心胶囊治疗射血分数保留型心衰的作用机制

目的 基于网络药理学及实验验证探讨芪苈强心胶囊治疗射血分数保留型心衰（heart failure with preserved ejection fraction,HFpEF）的作用机制。方法 将44个明确鉴定的芪苈强心胶囊体内代谢物检识有效成分，利用Swisstargetprediction、pharmmapper平台预测化合物靶点，OMIM、DisGenet、GenCard数据库中检索HFpEF疾病靶点；取交集靶点，利用String数据库和Cytoscape 3.7.2软件进行蛋白质-蛋白质相互作用（protein-protein interaction,PPI）和拓扑分析；Metescape平台对共同靶点进行基因本体（gene ontology,GO）功能富集分析及京都基因与基因组百科全书（Kyoto encyclopedia of genes and genomes,KEGG）通路富集分析。构建醋酸脱氧皮质酮（deoxycorticosterone acetate,DOCA）盐敏感型HFpEF大鼠模型，给予沙库巴曲缬沙坦或芪苈强心胶囊进行干预，给药8周后，利用小动物超声成像系统...     

胶囊内镜对小肠腔内隆起性病变诊断价值

目的探讨胶囊内镜对小肠腔内隆起性病变的诊断价值。方法计算小肠腔内隆起性病变的例数,描述隆起性病变的特点和分析影响因素,初步判断隆起性病变的性质。结果共发现45处隆起,其中22处证实为隆起性病变,约占隆起总数的48.9%,阴性排除率51.1%;胶囊内镜对体积小的隆起性病变观察清晰,体积、位置和小肠液等因素影响观察效果。结论胶囊内镜对隆起性病变具有较高的指导诊断价值。